Output details

A methodology for the comparative evaluation of alternative bioseparation technologies.

This paper shows how Mixed Attribute Decision Making can guide decision making during the development of high resolution purification techniques for biologics. The novelty of this Decisional Tools approach (see impact case study) is in the assignment of qualitative and quantitative measures describing the viability of operations upon scale-up and defining the potential of each using probabilistically-based scores showing the sensitivity to a range of input variables. This allows for the rapid identification of process alternatives. Such insights enable industry to target improvements of each method and supports on-going process development research with GE Healthcare (Dr Karol Lacki, karol.lacki@ge.com).