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15 - General Engineering

University of Sheffield

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Output 28 of 66 in the submission

Article title

Free Triiodothyronine Has a Distinct Circadian Rhythm That Is Delayed but Parallels Thyrotropin Levels

Type

D - Journal article

DOI

10.1210/jc.2007-2674

Title of journal

Journal of Clinical Endocrinology & Metabolism

Article number

Volume number

Issue number

First page of article

2300

ISSN of journal

0021972X

Year of publication

2008

URL

Number of additional authors

Additional information

Signal modelling revealed, for first time, the circadian release of thyroid hormones & that nightime rise in triiodothyronine is most potent at night. This led to patent application (PCT/GB2008/001433), filed by Diurnal Ltd (contact: Chief Executive Officer at martinwhitaker@diurnal.co.uk). Invention: polymer-engineered release mechanism for matching rhythm to improve therapy and quality-of-life. Underactive thyroid affects approximately 5% of over 60s and 25% of patients on thyroxine therapy have impaired quality-of-life. Diurnal Ltd has raised over £3M, has been awarded, with Sheffield University, an additional €4.2M to develop endocrine therapies & has products in Phase 1 clinical trial.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract