Output details
11 - Computer Science and Informatics
University of Oxford
Article title
A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis.
Type
D - Journal article
Title of journal
Biophys J
Article number
-
Volume number
101
Issue number
12
First page of article
2892
ISSN of journal
0006-3495
Year of publication
2011
Number of additional authors
9
Additional information
<28>
This article in Biophys J. is the first to give a thorough investigation using cardiac human and canine data, combined with stochastic simulation, of the role of intrinsic and extrinsic noise in the delayed rectifier potassium channel IKs in modulating temporal and spatial variability in ventricular cardiac repolarization. Pathological conditions resulting in gap junctional uncoupling or a decrease in repolarization reserve uncover the manifestation of IKs noise, resulting in enhanced ventricular variability.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Citation count
18
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
