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15 - General Engineering

Brunel University London

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Output 209 of 258 in the submission

Article title

Scalable Technology for the Extraction of Pharmaceutics (STEP): The transition from academic knowhow to industrial reality

Type

D - Journal article

DOI

10.1016/j.chroma.2011.01.016

Title of journal

Journal of Chromatography A

Article number

Volume number

1218

Issue number

First page of article

6114

ISSN of journal

00219673

Year of publication

2011

URL

http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271409&_user=545641&_pii=S002196731100046X&_check=y&_origin=article&_zone=toolbar&_coverDate=2011--09&view=c&originContentFamily=serial&wchp=dGLbVlV-zSkWb&md5=20b474360f6a99db450900e24a8c462f&pid=

Number of additional authors

Additional information

This paper is the first in a series addressing the technological readiness of counter-current chromatography instruments to become platform technology for the pharmaceutical industry. In this TSB High Value Manufacturing research programme, four case studies are presented that demonstrate the separation power of the instruments to end-user companies, GSK/Pfizer. The focus then changed to rapid method development, automation, continuous processing and instrument reliability culminating in a further publication (Sutherland et al., J.Chromatogr.A., 1282 (2013) 84) demonstrating a robust 24x7 laboratory instrument capable of processing a kilogram of crude per day.

(Keith Freebairn, Director, Second Generation Process Department, GSK– keith.w.freebairn@gsk.com)

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract