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15 - General Engineering

Brunel University London

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Output 210 of 258 in the submission

Article title

Scale-up of counter-current chromatography: Demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scale

Type

D - Journal article

DOI

10.1016/j.chroma.2009.03.040

Title of journal

Journal of Chromatography A

Article number

Volume number

1216

Issue number

First page of article

8787

ISSN of journal

00219673

Year of publication

2009

URL

http://www.sciencedirect.com/science/article/pii/S0021967309004373/pdfft?md5=fccaace7d785e82722a11d47f6390458&pid=1-s2.0-S0021967309004373-main.pdf

Number of additional authors

Additional information

This well cited paper, demonstrating predictable scale-up from test-tube to pilot scale counter-current chromatography, has directly led to the world’s first 18L CCC instrument, installed at Brunel, being used for 12 industrial purifications (some confidential) including separations of commercial insecticides for Dow AgroSciences LLC (DeAmicis, C. et al J. Chromatogr. A 1218 (2011) 6122-6127), API recovery from pharmaceutical waste streams for GSK (Ignatova, S. et al., CCC2012 conference, Hangzhou, China, 6-8 Aug 2012) and the purification of a drug candidate for AstraZeneca (Sumner, N., J. Chromatogr. A 1218 (2011) 6107– 6113).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract