Output details
11 - Computer Science and Informatics
University of Manchester
Article title
Analysis of a complete DNA-protein affinity landscape
Type
D - Journal article
Title of journal
Journal of the Royal Society Interface
Article number
-
Volume number
7
Issue number
44
First page of article
397
ISSN of journal
1742-5662
Year of publication
2010
URL
-
Number of additional authors
5
Additional information
<28> The concept of a fitness landscape is central to understanding how Evolution works in detail, and to an understanding of evolutionary dynamics. This paper is significant as it uses a new type of DNA microarray platform to synthesise over 1 million unique DNA molecules, giving one of the most complete pictures of a real biological fitness landscape ever made. We contribute to understanding through a detailed statistical analysis of the properties of the landscape, including enumeration of its optima, random walk analysis, comparison with artificial fitness landscapes, and by making all data available to the community.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Citation count
13
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
