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Predicting the pressure distribution during roll compaction from uniaxial compaction measurements

This paper presents a mechanistic study of the scale-up of roll compaction using uniaxial compaction a test easily performed and which requires only a small amount of material. It demonstrates that it is possible to predict the behaviour of powder during roll compaction from uniaxial compression measurements only if powder flow characteristics are duly considered. This study indicates that uniaxial compaction is useful for screening different formulations to rank their expected performance in roll compaction. This provides a valuable guideline for science-based formulation-development for the particulate product manufacture industries where roll compaction can often improve process efficiency and product quality.