Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Sheffield : B - Materials Science and Engineering
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Output 0 of 0 in the submission
Article title
Shear stress induces osteogenic differentiation of human mesenchymal stem cells
Type
D - Journal article
Title of journal
Regenerative Medicine
Article number
-
Volume number
5
Issue number
5
First page of article
713
ISSN of journal
1746076X
Year of publication
2010
URL
-
Number of additional authors
3
Additional information
Stem cells are differentiated into bone cells by steroids that have harmful side effects or growth factors that are too expensive for routine medical use. In collaboration with US partners, we established a technique to apply fluid flow to differentiating stem cells. We demonstrated, using donated human stem cells and polymerase chain reaction analysis, that flow culture can be an alternative method to pre-differentiate cells for clinical use. This work led to a collaboration with a cell culture products company Orla-Protein-Technologies (OPT) to extend the concept to 3D dynamic culture (£32k from OPT, £60k from METRC, grant M4090).
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
