Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Sheffield : B - Materials Science and Engineering
Physics of Nanomechanical Biosensing on Cantilever Arrays
This reported the first quantitative multiscale model describing the transduction of specific biochemical reactions into micromechanical cantilever bending motion. By considering the chemical, elastic and entropic properties of cantilever and sensing layer, it enabled predictive design of surface stress biosensors with ultrathin nanomechanical devices. Excellent quantitative agreement with experiments showed that the biaxial elastic modulus of the sensing layer is a key figure of merit for improved detection sensitivities at the nanoscale. This advance has enabled the use of sensitive surface stress modes to analyse small molecule/surface interactions, and to investigate mechanical mechanisms of antibiotic interaction with bacteria (doi:10.1042/BST20120082).
