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Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle

A novel microfluidic strategy for fabrication of hydrogel microbeads was developed based on a centrifugally driven pulse-free flow through radially arranged micronozzles. The fabricated chitosan microbeads were collected directly in a standard Eppendorf tube to allow easy post-production handling without cross contamination. A novel mathematical model for the prediction of the size and production rates of microbeads was developed and validated. This research was supported by an Alexander von Humboldt scholarship awarded to Dr Vladisavljevic and conducted in collaboration with Freiburg University (Prof. Zengerle Group: zengerle@imtek.uni-freiburg.de). Micronozzles used in this work were commercialised in the PipeJet-TipTM nanodosage systems.