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15 - General Engineering

Brunel University London

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Article title

Comparison of preparative reversed phase liquid chromatography and countercurrent chromatography for the kilogram scale purification of crude spinetoram insecticide

Type

D - Journal article

DOI

10.1016/j.chroma.2011.06.073

Title of journal

Journal of Chromatography A

Article number

Volume number

1218

Issue number

First page of article

6122

ISSN of journal

00219673

Year of publication

2011

URL

http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271409&_user=545641&_pii=S0021967311009034&_check=y&_origin=article&_zone=toolbar&_coverDate=2011--09&view=c&originContentFamily=serial&wchp=dGLzVBA-zSkWb&md5=9ce8d4a95bf7953cacd94efb83c616df&pid=

Number of additional authors

Additional information

This is the first ever comparison between High Performance Counter-current Chromatography (HPCCC, the new liquid-liquid technology) and Preparative High Performance Liquid Chromatography (HPLC, the liquid-solid state-of-the-art) for an industrial scale application. It showed the new technology used less than a third of the solvent and had more that 3 times the throughput of HPLC. It also demonstrated 44x loading with 17.5x the run time resulting in only 14 runs/kg compared to 460 with preparative HPLC. HPCCC clearly offers significant solvent cost savings and has since been effectively used by industry for a number of unpublished contract separations of new drugs.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract