Output details

Generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after THA

Significance of output:

Bone responds to changes in its mechanical environment by removing unloaded tissue and adding new bone in highly loaded areas. Here we show that numerical models that include detailed subject specific muscle and joint forces rather than simplified or more generic loads were able to accurately predict the extent of bone adaptation following hip replacement. The unprecedented in vivo verification of the predictive power of the bone adaptation model provides the essential basis for using such approaches to better match patients to existing implants and develop new devices in order to preserve bone better and ensure longer lasting implant fixation.