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Output details

13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Sheffield : B - Materials Science and Engineering

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Output 32 of 128 in the submission

Article title

Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib

Type

D - Journal article

DOI

10.1182/blood-2008-04-150227

Title of journal

Blood

Article number

Volume number

112

Issue number

First page of article

3835

ISSN of journal

15280020

Year of publication

2008

URL

http://www.ncbi.nlm.nih.gov/pubmed/18633129

Number of additional authors

Additional information

This is the first ever study using Raman spectroscopy to monitor dietary flavonoids directly in human-plasma, specifically the detection of quercetin and myricetin. These are important as they inhibit the effectiveness of an anticancer drug, bortezomib, on leukaemia cells. This research has been employed by a number of clinical/non-clinical researchers (e.g., Ohio, Wayne, McGill Universities) internationally to identify inhibitor functions and drug manipulations of flavonoid activity.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract