Output details

Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure 'biomarker' signals and induction of inflammatory, innate immune and apoptotic pathways

This output pioneers the chronic exposure of flounder to multiply polluted estuarine sediments causing increases in the hepatic expression of genes involved in innate immunity, inflammation and apoptotic pathways. Genes commonly employed as environmental contaminant exposure biomarkers (e.g. CYP1A, vitellogenin, metallothionein) were not affected, or were changed contrary to expectation in this experimental system, suggesting they may be most useful in monitoring acute spill, or point-source contaminant inputs to the environment. This work was funded by the UK NERC grants NE/C507688/1, NE/C50766/1 and NE/C50767x/1 and a fellowship from the Co-operative Research Programme of the Organisation for Economic Co-operation and Development.