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15 - General Engineering

University of Edinburgh (joint submission with Heriot-Watt University)

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Output 24 of 305 in the submission

Article title

A versatile CARS microscope for biological imaging

Type

D - Journal article

DOI

10.1002/jrs.2249

Title of journal

Journal of Raman Spectroscopy

Article number

Volume number

Issue number

First page of article

757

ISSN of journal

0377-0486

Year of publication

2009

URL

http://onlinelibrary.wiley.com/doi/10.1002/jrs.2249/abstract

Number of additional authors

Additional information

The innovative development of a hybrid CARS-AFM microscope is reported, together with its capability to provide the first 3-D topographical images of cancerous breast tissue at 10 nm resolution. Further validation of the microscope’s potential importance to biomedical research includes applications to cancer (DoI:10.1002/jrs.2622), stem cells (DoI:10.1117/1.JBO.17.11.116011) and neurodegenerative diseases (DoI:10.1117/12.889772). This microscope can be hybridised with other non-invasive imagining modes, and this was highlighted in “Annual Review of Analytical Chemistry” (DoI:10.1146/annurev-anchem-062011-143152). Through CRUK funding (C157/A12753, £250k, with Downes as co-I) a dedicated facility for this instrument now exists at the Edinburgh Cancer Research UK Centre.

Interdisciplinary

Yes

Cross-referral requested

Research group

A - Manufacturing & Materials

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract