Output details
15 - General Engineering
University of Nottingham
Article title
Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage
Type
D - Journal article
Title of journal
American Journal of Physiology. Cell Physiology
Article number
-
Volume number
303
Issue number
12
First page of article
C1252
ISSN of journal
0363-6143
Year of publication
2012
Number of additional authors
3
Additional information
The novel calcium-permeable ion channel identified in this work may underlie the electrical and metabolic insults which produce lens cataract. This ion channel is therefore an attractive target for anti-cataract therapies, while its constitutive activity in the lens is likely to be crucial to its hydration and metabolic homeostasis. Data has been integrated into a finite element model of the ocular lens, under the international Physiome project. (p.hunter@auckland.ac.nz)
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
