Output details
15 - General Engineering
Liverpool John Moores University
Actin Bundling and Polymerisation Properties of Eukaryotic Elongation Factor 1 Alpha (eEF1A), Histone H2A-H2B and Lysozyme in vitro
A stream of GERIs cell mechanics work, this paper represents a significant step in engineering knowledge applied to understanding how cancer leads to cells becoming mechanically compromised through actin disorganisation. The work involved using advanced microscopy techniques to quantify changes to actin structure. This multidisciplinary paper is important as it clearly established the link between organisation of the actin structure and mechanical integrity. It resulted in new international collaborations and in the development of a new French National Research Agency (ANR) project proposal to develop novel software tools that can be used to model actin organisation in cancer cells.