Output details
15 - General Engineering
Imperial College London
Article title
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.
Type
D - Journal article
Title of journal
Arteriosclerosis Thrombosis and Vascular Biology
Article number
-
Volume number
29
Issue number
11
First page of article
1851
ISSN of journal
1524-4636
Year of publication
2009
URL
-
Number of additional authors
12
Additional information
This study identified Nrf2 as a key molecule in the flow-mediated protection of endothelial cells from activation leading to atherosclerosis. It has stimulated our group and others to test broccoli as a treatment for atherosclerosis, since broccoli contains compounds that affect Nrf2. Follow on funding: BHF programme grant (RG/11/13/29055, £750,000) to further study and validate genes related to sensing flow. This reseearch resulted in invitations to give 2 keynotes (FCVB, London 2012 and ESC, Istanbul 2009), one plenary (Artery, Ghent 2008), and 12 seminars.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
