You are in : Home » Results & submissions » Select UOA » 15 - General Engineering » View submission: Brunel University London » Outputs » Detail

Output details

15 - General Engineering

Brunel University London

Return to search Previous output Next output

Output 176 of 258 in the submission

Article title

New 18-l process-scale counter-current chromatography centrifuge

Type

D - Journal article

DOI

10.1016/j.chroma.2008.11.097

Title of journal

Journal of Chromatography A

Article number

Volume number

1216

Issue number

First page of article

4201

ISSN of journal

00219673

Year of publication

2008

URL

http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271409&_user=545641&_pii=S0021967308021146&_check=y&_origin=article&_zone=toolbar&_coverDate=08-May-2009&view=c&originContentFamily=serial&wchp=dGLzVlV-zSkWb&md5=c45c60dd3a9d7cfbad3466e42ee3f4f8&p

Number of additional authors

Additional information

This highly cited paper was the culmination of two Research Council grants (GR/R03143/01, BBD524583/1). A new small footprint 18-litre coil planet centrifuge was developed using a new “silent” belt drive system and on-column cooling system. Linear scale-up was demonstrated. This unit became the benchmark for industrial purification runs of kilogram quantities of pure drug for clinical trials. A number of successful applications have been performed in confidence for industry. The only one that allowed publication demonstrated a three-fold reduction in cost and solvent usage when compared to competitive solid phase chromatography (DeAmicis et al, J. Chromatogr. A, 1218 (2011) 6122)

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract