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Output details

15 - General Engineering

Brunel University London

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Output 200 of 258 in the submission

Article title

Rapid linear scale-up of a protein separation by centrifugal partition chromatography

Type

D - Journal article

DOI

10.1016/j.chroma.2008.02.092

Title of journal

Journal of Chromatography A

Article number

Volume number

1190

Issue number

1-2

First page of article

ISSN of journal

00219673

Year of publication

2008

URL

http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271409&_user=545641&_pii=S0021967308003105&_check=y&_origin=article&_zone=toolbar&_coverDate=09-May-2008&view=c&originContentFamily=serial&wchp=dGLbVlB-zSkzk&md5=0b7c3ebb48cea7f92db0fb30b803b5fa&p

Number of additional authors

Additional information

This highly cited paper was the culmination of a 3-year BBSRC grant (BB/C506364/1) to develop new technologies for the purification of proteins. It investigated a new double cascading chamber design of centrifugal partition chromatography and demonstrated excellent resolution in the model separation of myoglobin and lysozyme using aqueous two-phase systems (ATPS) which are a gentle host medium for proteins. This was then predictably scaled up from lab prep to pilot industrial scale with an excellent fit between theory and practice. The industrial success of this process can be verified by Francois Couillard director of Armen Instruments - francois.couillard@armen-instrument.com

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract