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Preparative isolation and purification of ginsenosides Rf, Re, Rd and Rb1 from the roots of Panax ginseng with a salt/containing solvent system and flow step-gradient by high performance counter-current chromatography coupled with an evaporative light scattering detector

This highly cited paper has resulted from a collaborative research programme between Brunel and Tsinghua Universities. Qi worked at Brunel for 6 months on fractionating newly identified Ginsenosides from Ginseng, an important Chinese herb whose active constituents are forming the ingredients for new modernised Chinese medicines being developed by Xiangxue Pharmaceuticals (XXP) from Guangzhou, China. The technology used was Brunel’s High Performance Counter-current Chromatography (HPCCC) developing novel phase systems to counteract emulsification. The success of this research led to both Tsinghua University and XXP purchasing Preparative HPCCC devices and continuing development research in China. (Dr David Rooke, david.rooke@dynamicextractions.com)