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15 - General Engineering

Brunel University London

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Output 172 of 258 in the submission

Article title

Multiple dual-mode countercurrent chromatography applied to chiral separations using a (S)-naproxen derivative as chiral selector

Type

D - Journal article

DOI

10.1016/j.chroma.2009.10.006

Title of journal

Journal of Chromatography A

Article number

Volume number

1216

Issue number

First page of article

8505

ISSN of journal

00219673

Year of publication

2009

URL

http://www.sciencedirect.com/science/article/pii/S0021967309014812/pdfft?md5=e8ceab98e52531be6386aa58aba21501&pid=1-s2.0-S0021967309014812-main.pdf

Number of additional authors

Additional information

This is the first time the power of multi-dual-mode(MDM) counter-current chromatography(CCC) has been demonstrated for the separation of chiral compounds. It also shows how the chiral selector can be recycled and re-used many times. The use of MDM in this case where the CCC operation is alternately switched from normal to reversed phase operation affectively enable high resolution separations on a short column by effectively lengthening it. This is also the first time successful chiral separations have been achieved using the new high performance CCC technology and has triggered further development of CCC chiral applications (Mekaoui et al, J.Chromatogr.A,1218(2011)6061)

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract