Output details
15 - General Engineering
Keele University
Article title
Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses.
Type
D - Journal article
DOI
Title of journal
Nat Neurosci
Article number
-
Volume number
13
Issue number
1
First page of article
45
ISSN of journal
1546-1726
Year of publication
2010
Number of additional authors
11
Additional information
This paper resolved the debate about the likely calcium sensor used in cochlear hair cells to control neurotransmitter release. It is the first report of synaptotagmins, a major group of synaptic regulators, in the cochlea and shows that their expression is developmentally sensitive. It led to further collaboration with the group at Sheffield (Furness et al, 2013; PNAS, 110, 13898; Zampini et al, PLosBiol,:e1001048) that are changing perceptions of how cochlear hair cells function. It was partially supported by the Henry Smith Charity and also brought income into Keele from Sheffield.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
