Output details
15 - General Engineering
King's College London
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Article title
Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity
Type
D - Journal article
Title of journal
Magnetic Resonance in Medicine
Article number
-
Volume number
62
Issue number
5
First page of article
1300
ISSN of journal
0740-3194
Year of publication
2009
URL
-
Number of additional authors
8
Additional information
This paper is the first to identify a reporter molecule (difluorobenzoyl glutamic acid) for measuring the activity of a gene directed pro-drug activating enzyme (GDEPT) carboxypeptidase. GDEPT is an approach for suicide gene cancer and currently the subject of a clinical trial. There are currently no imaging techniques able to measure the efficacy of this therapy. The imaging methods developed here probe the activity of enzyme expression directly which underpins this therapy. We have extended the work to in vivo imaging [Smyth, NMR Biomed, 2011] and developed an MRI contrast technique for imaging this promising treatment [Yann, Mol. Imag. Biol, 2013].
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
