Output details
15 - General Engineering
Imperial College London
Article title
Engineering of regulated stochastic cell fate determination
Type
D - Journal article
Title of journal
Proceedings of the National Academy of Sciences of the United States of America
Article number
-
Volume number
110
Issue number
26
First page of article
10610
ISSN of journal
0027-8424
Year of publication
2013
URL
-
Number of additional authors
5
Additional information
This is the first synthetic biology investigation of how stochasticity in gene networks defines differentiation in eukaryotes. Our biological engineering expertise, combined with mathematical prowess of our collaborators, gave an experimentally-verified model of how cell fate is determined. Early presentation of this work was invited for plenary talks at international synbio and UK yeast conferences (SB6.0, BYG2013) and helped secure a £1.5M grant to re-engineer the yeast genome (BB/K019791/1). The DNA materials developed for this paper are now used to teach undergraduate synthetic biology at MIT, leading to Dr Ellis being named an editor of the journal ACS Synthetic Biology.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
