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High-resolution magnetic resonance myocardial perfusion imaging at 3.0-Tesla to detect hemodynamically significant coronary stenoses as determined by fractional flow reserve

Fractional flow reserve (FFR) is recognised as the gold standard for assessment of the severity of coronary artery stenosis and been shown to be the best clinical determinant of patient selection for interventions. In this work we have developed and applied an MR myocardial perfusion technique using k-space and time sensitivity encoding to achieve 1.2x1.2mm resolution and showed it to be highly sensitive and specific in identifying coronary stenoses compared to FFR. Razavi was the PI, Redwood carried out the FFR procedures and Plein the MRI scans. The paper was published in one of the leading cardiovascular journals.