Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Bradford
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Article title
Polymorphic transformation of artemisinin by high temperature extrusion
Type
D - Journal article
Title of journal
CrystEngComm
Article number
-
Volume number
15
Issue number
32
First page of article
6297
ISSN of journal
1466-8033
Year of publication
2013
URL
-
Number of additional authors
5
Additional information
This paper describes a new technique to produce an improved, stable form of artemisinin, a globally important drug used in the treatment of malaria. This work reported continuous polymorphic transformation of artemisinin for the first time, using a solvent-free extrusion based process. Solvent based processes are unable to create a stable form of the desired polymorph. A patent application, with Kelly as co-inventor, on this technology (PCT/GB2013/051248) demonstrates the commercial potential of this technique, which has also been proven with other drugs.
Interdisciplinary
-
Cross-referral requested
-
Research group
A - Advanced Materials Engineering
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
