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Measuring the strength of dermal fibroblast attachment to functionalized titanium alloys in vitro.

Implants and coatings need to be engineered to enhance the attachment of soft tissue. This enables devices to become seamlessly integrated with the soft tissues of the musculoskeletal system, improving functional outcomes and patient quality of life. It is vital to have accurate methods of assessing the strength of attachment of cells to biomaterial surfaces. This study developed a novel flow apparatus that could calculate the strength of attachment. The directly correlated to immunofluorescent assays previously used to assess cell attachment strength. The results enable us to continue to use the later assay to assess cell attachment, saving considerable funding.