Output details
11 - Computer Science and Informatics
University of Oxford
Species-Specific Pulmonary Arterial Asymmetry Determines Species Differences in Regional Pulmonary Perfusion
<28>
This work presented the development of a computational model of the pulmonary circulation in a sheep. Central vascular geometry was segmented from CT. A finite element model of the full network was created using a volume-filling algorithm. Blood flow was predicted using the 1D Poiseuille flow equation. Blood flow predictions were compared across sheep and human.
This was a novel study that presented the ability to use a model to translate functional predictions/measurements in animals to those in humans. It also provided evidence for a debate relating the importance of vascular branching structure to the distribution of pulmonary blood flow.