Output details
15 - General Engineering
University of Southampton
Acute toxicity and prothrombotic effects of quantum dots: impact of surface charge
Significance of output:
The development of nanotechnology greatly depends on the expansion of sound and authoritative information on the risks involved. From a number of fundamental properties, surface charge of nanoparticles has been found to exert a crucial role on their toxicity to humans. This work investigated the in vivo acute toxicity of surface charge of commercially available quantum dots (QDs) which are widely used as diagnostic probes for in vivo and in vitro imaging in medical applications. This comprehensive evaluation study of the hazard of injected QDs is the first which emphasized the importance of surface charge in assessing nanotoxicity.