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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Cambridge
Extrusion-spheronisation of microcrystalline cellulose pastes using a non-aqueous liquid binder.
Extrusion-spheronisation is a popular pharmaceutical granulation technique but encounters problems when the active ingredient is incompatible with water. This study demonstrated that non-aqueous liquid binder selection can be guided by biopolymer chemistry. The group’s leading work on the mechanics of extrusion-spheronisation resulted in a plenary lecture on the topic at the European PharmSci Fair in Prague, 2011. The work was supported by MSD (contact Dr Christian Seiler, email available) and the company funded a follow-on Dorothy Hodgkin PhD studentship in this area. Author Mascia moved on to the MIT/Novartis institute to a key role in developing continuous pharmaceutical granulation.