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13 - Electrical and Electronic Engineering, Metallurgy and Materials

Imperial College London : B - Metallurgy and Materials

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Article title

Silica-Gelatin Hybrids with Tailorable Degradation and Mechanical Properties for Tissue Regeneration

Type

D - Journal article

DOI

10.1002/adfm.201000838

Title of journal

Advanced Functional Materials

Article number

Volume number

Issue number

First page of article

3835

ISSN of journal

1616-301X

Year of publication

2010

URL

Number of additional authors

Additional information

Bioceramics are currently used in orthopaedics but are brittle. This paper describes synthesis of flexible hybrid (silica/gelatin) scaffolds with covalent coupling that can share load with host tissue and degrade congruently at a controlled rate. Degree of coupling gave control of degradation rate and mechanical properties independent of polymer content. Used by leading researchers: Abe (Shinshu, Japan); Rahaman (Missouri MS&T); Vallet-Regi (Marid, Spain); Hanke (Dresden, Germany); Coradin (Paris, France). Contributed to patent WO 2009/030919 A2, licensed by RepRegen Ltd. Led to £100k TSB (process up-scale) and EPSRC Challenging Engineering grants (£1.5M). Keynote at World Biomaterials Congress 2012.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract