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Output details

15 - General Engineering

Imperial College London

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Output 69 of 109 in the submission

Article title

Morphological evidence for a change in the pattern of aortic wall shear stress with age.

Type

D - Journal article

DOI

10.1161/ATVBAHA.110.219683

Title of journal

Arteriosclerosis Thrombosis and Vascular Biology

Article number

Volume number

Issue number

First page of article

543

ISSN of journal

1524-4636

Year of publication

2011

URL

Number of additional authors

Additional information

A major focus of cardiovascular biomechanics is the causal role played by fluid dynamic forces in atherosclerosis. For decades, the consensus has been that low wall shear stress triggers the disease. Our paper provides strong evidence that this consensus is wrong. The methods were developed in a collaboration with Georgia Tech, led by us (Am J Physiol Heart Circ Physiol. 2010;298:H536-H544). The heterodox conclusion led to the award of a £1.2M BHF Programme Grant (RG/11/5/28743, PI: Weinberg) investigating shear and atherosclerosis, and to an invited talk at the 2011 international Microscale Modeling in Biomechanics and Mechanobiology conference, Portugal.

Interdisciplinary

Yes

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract