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Output details

15 - General Engineering

Imperial College London

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Output 91 of 109 in the submission

Article title

Stretching single talin rod molecules activates vinculin binding.

Type

D - Journal article

DOI

10.1126/science.1162912

Title of journal

Science

Article number

Volume number

323

Issue number

5914

First page of article

638

ISSN of journal

1095-9203

Year of publication

2009

URL

Number of additional authors

Additional information

We used nanotechnological and biophysical techniques to reveal that mechanical unfolding of protein domains is a cellular mechanism for transforming mechanical stimuli into biochemical signals. Selected by ScienceWatch (Thomson Reuters) as the most influential 2009 article in the field of Biology and Biochemistry (http://archive.sciencewatch.com/dr/fbp/2009/09octfbp/). Other publications in top international journals highlighted the repercussions of this research: Schwartz "The force is with us," Science 2009;323:588-589, Heinrichs "Switch and Stretch," Nature Reviews Molecular Cell Biology 2009 doi:10.1038/nrm2642. A 5-year ERC starting grant (€2M) was awarded based on this work. Led to speaker invitation, International Congress of the Spanish Biophysical Society 2012.

Interdisciplinary

Yes

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract