Output details
15 - General Engineering
Imperial College London
Article title
Integrin-dependent force transmission to the extracellular matrix by alpha-actinin triggers adhesion maturation
Type
D - Journal article
Title of journal
Proceedings of the National Academy of Sciences of the United States of America
Article number
-
Volume number
110
Issue number
15
First page of article
E1361
ISSN of journal
0027-8424
Year of publication
2013
URL
-
Number of additional authors
5
Additional information
Focal adhesion complexes regulate critical physiological and pathological processes at the cellular level. This article showed the dynamic interplay between two mechanotransducers in these complexes, talin and α-actinin. It led to invited seminars in several universities to present the work (e.g University of Sheffield; University of Leeds), and to a joint project with Dr. Julien Gautrot (QMUL) investigating the role of these two molecules in hierarchical sensing of substrate nano-topography. After a preliminary submission, a full joint grant application has been invited by the Leverhulme Trust.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
