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Output details

15 - General Engineering

Imperial College London

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Output 73 of 109 in the submission

Article title

Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles.

Type

D - Journal article

DOI

10.1073/pnas.1105116108

Title of journal

Proceedings of the National Academy of Sciences of the United States of America

Article number

Volume number

108

Issue number

First page of article

16539

ISSN of journal

1091-6490

Year of publication

2011

URL

Number of additional authors

Additional information

Large molecule drugs are normally unable to cross the blood-brain barrier (BBB), preventing treatment of brain diseases. Here we showed that the BBB can be temporarily opened with mechanical stress created by ultrasonically-activated systemic microbubbles. Novel ultrasonic sequences minimised point stress, and safely improved dose and distribution. This is the first demonstration of the noninvasive and localised neuronal delivery of large molecules. It was highlighted in Nature Reviews Neurology (2011;7:597) and initiated international collaborative projects with neuroscientists (Prof. Götz, University of Queensland) and clinicians (Prof. Small, Columbia University).

Interdisciplinary

Yes

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract