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Dual sensing of hairpin and quadruplex DNA structures using multicolored peptide nucleic acid fluorescent probes.

High-throughput profiling/sensing of nucleic acids has recently emerged as a highly promising strategy for the detection of a broad range of human diseases, including cancer. In this article, we validate a new approach for sensing multiple DNA targets simultaneously using non-overlapping fluorogenic probes. In 2013, I was awarded a 1-year grant (EPSRC/Wellcome Trust, £71k) to develop a fluorescence assay based on this concept for identifying new biomarkers of osteoarthritis. The work was presented in 2013 at the 47th European Symposium on Biological and Organic Chemistry and at an invited lecture given at Pavia University (Italy).