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Development of a Bolus Injection System to Achieve Storage and Controlled Delivery of Nanoparticles to Human Lung

This paper focuses on the design and development of an automated bolus delivery system for the human respiratory system. It examines existing (manual) methods and their limitations. This is followed by the derivation of detailed design specifications and implementation of the control system in real-time. A novel feature of the design is that it analyses varying breath-cycles and estimate all parameters necessary to calculate & deliver the dosage at any desired point in the breathing cycle. This feature can also be extended to study targeted drug delivery and to provide quantitative diagnostic data of the respiratory system.