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Output details

13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Sheffield : B - Materials Science and Engineering

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Output 91 of 128 in the submission

Article title

Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell

Type

D - Journal article

DOI

Title of journal

European Cells and Materials

Article number

Volume number

Issue number

First page of article

ISSN of journal

14732262

Year of publication

2010

URL

Number of additional authors

Additional information

We showed, for the first time, that the harmful steroid dexamethasone, used to culture human stem cells and induce bone formation, can be replaced by short bouts of mechanical stimulation. This validated a bioreactor culture protocol previously developed in mature bone cells in partnership with Bose-ElectroForce. Influence is demonstrated by the highlighting of this study in a newsletter and application brief by Bose ElectroForce systems group (http://worldwide.bose.com/electroforce/assets/pdf/appBriefs/appbrief_Stem_Cell.pdf) as an example of how their bioreactors can be used to direct stem cell differentiation (contact: Darren_Burke@bose.com).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract