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Output details

13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Sheffield : B - Materials Science and Engineering

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Output 53 of 128 in the submission

Article title

Hyperbranched poly(NIPAM) polymers modified with antibiotics for the reduction of bacterial burden in infected human tissue engineered skin

Type

D - Journal article

DOI

10.1016/j.biomaterials.2010.08.084

Title of journal

Biomaterials

Article number

Volume number

Issue number

First page of article

258

ISSN of journal

01429612

Year of publication

2011

URL

http://www.ncbi.nlm.nih.gov/pubmed/20933276

Number of additional authors

Additional information

We developed hyperbranched poly (NIPAM) polymers functionalised with antibiotics sensitive to the presence of bacteria. We applied these novel polymers to our tissue engineered human skin model of an infected burn wound. When the polymers were removed from the infected skin, they bound bacteria, significantly reducing the bacterial load in the infected skin model. This approach to reducing bacterial contamination of wounds has now attracted TSB funding led by Smith & Nephew (£350k) to make an impact in the management of chronic wounds in man.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract