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Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons

-International collaborative research into nano-Ag’s functionality-toxicity in rat CA1-pyramidal-neurons which control feeling, memory and mode of all mammalian lives.

-Effects of nano-dosage incrementally increased excitability in rat CA1 pyramidal neurons, confirming again the safety threshold of 0.05 wt.% in the nano-suspension.

-The toxicity safety mechanism level was defined, which is of concern for most for nano-applications (over £1billion global investment during past 10 years).

-The significance is that this research paper gave evidence to prove a minimum-dosage-window exists (0.05wt.%) for a guaranteed safe-use of nano-particles.

-Led to a breakthrough in the use of nanomaterial-nanotechnology in bio-medical-healthcare applications.