Output details

Attenuation of Wave Reflection by Wave Entrapment Creates a "Horizon Effect" in the Human Aorta

Interdisciplinary research with cardiologists from Imperial College that elucidated an important mechanism underlying the augmentation of aortic blood pressure. It combines the algorithm in Output 1 with clinical measurements to show that there are multiple reflection sites in the arterial network sending pulse waves back to the aortic root with a magnitude that is attenuated with distance. This prevents distal waves from reaching the heart. It provides valuable insight into the role of wave reflections in hypertension and heart failure. It is the basis of a BHF project grant on the non-invasive assessment of aortic stiffness by pulse wave analysis.