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Apathy, depression, and motor symptoms have distinct and separable resting activity patterns in idiopathic Parkinson disease

This paper was recognised by Y. Kwak (youngbin.kwak@duke.edu) and co-workers at University of Michigan as significant for understanding and identifying key aspects of Parkinson’s disease (PD), as it shows that our reported resting activity analysis gives “measures correlated with apathy, depression and motor symptom severity in PD”. Kwak and co-workers made this observation in (Kwak et al, Front Syst Neurosci. 2012; 6: 52), where they extend this research area to show that frequency domain analyses of resting state BOLD fMRI signals may provide a useful means to study the pathophysiology of PD and the physiology of the brain's dopaminergic pathways.