Output details
15 - General Engineering
University College London
Article title
A novel nanocomposite polymer for development of synthetic heart valve leaflets
Type
D - Journal article
Title of journal
ACTA BIOMATER
Article number
-
Volume number
5
Issue number
7
First page of article
2409
ISSN of journal
1742-7061
Year of publication
2009
URL
-
Number of additional authors
5
Additional information
In this study, a recently developed nanocomposite polymer, already patented by UCL Business (Pat. No. WO2005070998), is assessed for heart valve applications. This has involved a complete investigation of the material behaviour in term of biological and mechanical performance. Following this validation, this nanocomposite polymer has been used in valve prototypes, and selected for a novel transcatheter valve under development at UCL (see Publication 3). A successive in vitro implantation study in a large animal model has confirmed in vitro findings about biocompatibility, non-toxicity, and resistance to degradation, inflammation or capsule formation.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
