Output details
15 - General Engineering
University College London
Article title
A novel tissue engineered three-dimensional in vitro colorectal cancer model.
Type
D - Journal article
Title of journal
Acta Biomater
Article number
-
Volume number
9
Issue number
8
First page of article
7917
ISSN of journal
1878-7568
Year of publication
2013
Number of additional authors
3
Additional information
In this work a novel in vitro 3D model for cancer was developed in collaboration with cancer biologists and clinicians. The 3D architecture of colorectal cancer, including a dense tumour mass within a ‘normal’ stroma tissue was engineered, and invasion of tumour cells into the stroma was established. In this paper we demonstrate the engineering of a biomimetic model of cancer which has the potential to be used as an in vitro tool for drug testing, as well as a competitive model for the current use of animal xenograft models.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
