Output details
15 - General Engineering
University of Warwick
Structural identifiability of surface binding reactions involving heterogeneous analyte : application to surface plasmon resonance experiments
Using these results we were able to demonstrate crucial limitations in standard methods for estimating binding affinity from SPR, to clinical scientists and practitioners at the British Renal Society/Renal Association Conference 2011. The results lead to approval for a PhD student to develop a robust approach to determining antibody affinity from SPR; necessary for understanding the role of donor specific antibodies in the rejection of renal transplants (with Engineering, Warwick Medical School and NHS Blood and Transplant (contact Dr Briggs: david.briggs@nhsbt.nhs.uk)). The student is also working with a CLRN Clinical Research Fellowship based a University Hospital Coventry (Dr Daga: sunildaga@nhs.net).