Output details
15 - General Engineering
King's College London
Article title
Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias
Type
D - Journal article
Title of journal
Brain
Article number
awr028v1
Volume number
134
Issue number
4
First page of article
979
ISSN of journal
0006-8950
Year of publication
2011
URL
-
Number of additional authors
7
Additional information
Building on earlier work that showed in rats, controls, and epilepsy patients that [11-C]CNS5161 was a promising PET tracer for imaging activated NMDA channels, this paper employed the same novel tracer to provide the first evidence of excessive glutamate neurotransmission in Parkinson’s disease leading to specific pathophysiological effects. Hammers provided the scan acquisition and analysis methodology, while patients were recruited by Brooks. This work suggests new therapeutic avenues and has led to a collaboration with GE which has generated an improved 18-F labelled tracer [McGinnity, J Nucl Med, 2013].
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
