Output details
15 - General Engineering
King's College London
Article title
Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008
Type
D - Journal article
Title of journal
Journal of Nuclear Medicine
Article number
-
Volume number
54
Issue number
1
First page of article
139
ISSN of journal
0161-5505
Year of publication
2013
URL
-
Number of additional authors
8
Additional information
This publication describes the synthesis and study of a new radiolabelled molecule for imaging imidazoline-I2 receptors in vivo using Positron Emission Tomography (PET). I2 receptors are located in the brain and are known to be disrupted in a range of neurological disorders, including Alzheimer’s Disease. These studies, performed in pigs, represent the first ever successful PET imaging of I2 receptors and are in the process of translation in to a human study. This new radiotracer has the potential of enabling early diagnosis and treatment of neurological disorders, before structural changes develop that are seen with standard imaging techniques.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
