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Magnetic resonance elastography for the noninvasive staging of liver fibrosis

Hepatitis C represents a worldwide health problem leading to liver fibrosis which can turn into cirrhosis and eventually into hepatocellular carcinoma. The non-invasive staging of liver fibrosis represents a major issue in the treatment of fibrosis since repetitive biopsies are not possible and serum markers are unreliable for low and medium grade fibrosis. This analysis on 120 patients demonstrates that the non-invasive measurements liver stiffness can be used as biomarker for the distinction between low grade, mid grade, and high grade fibrosis. These results had a major impact in motivating both GE and SIEMENS to invest into this technique.