Output details

Fluid-solid coupling for the investigation of diastolic and systolic human left ventricular function

This paper develops a coupled model of hemodynamics and tissue mechanics in the beating heart. Defining the ALE Navier-Stokes equations and an anisotropic hyperelastic strain energy formulation for the myocardium, this paper goes on to outline their coupling using non-conforming techniques which enable, for the first time, appropriate numerical approximation of both fluid and solid. A model of tissue contraction is also built based on experimental data measured in insolated cardiomyocytes. The model is then used to simulate the beating heart through the cardiac cycle and the results are analyzed showing the interaction of hemodynamics and mechanics in the heart.